HEALTH SOLUTIONS:： RECOMMENDED USE：Source of essential fatty acids for the maintenance of good health. DOSAGE FORM：Softgels RECOMMENDATIONS：Adults take 2 softgels, one to three times daily. DESCRIPTION: Each softgel of Quest Evening Primrose Oil 1,000 mg contains 1,000 mg of Evening Primrose (Oenothera biennis) seed oil, providing 739 mg of Linoleic acid, 92 mg of Gamma linoleic acid and 70 mg of Oleic acid. This product contains no artificial preservatives, colours, or flavours, or corn, dairy, egg, gluten, shellfish or sulfites. Causes of Defi ciency: Inability to convert LA to GLA efficiently.. Symptoms of Defi ciency: Inflammation. Complementary Nutrients: A healthy diet. HOW IT WORKS: Evening primrose oil (EPO) is high in gamma-linolenic acid (GLA), which may suppress inflammation through its metabolism to dihomo- gamma-linolenic acid (DGLA), which, in turn, can competitively inhibit the pro-inflammatory 2-series prostaglandins and 4-series leukotrienes. The incorporation of GLA and its metabolites in cell membranes may also play a role in the possible anti-inflammatory, antithrombotic, antiatherogenic, and antiproliferative actions of EPO DID YOU KNOW… Evening primrose oil has been used since the 1930’s to treat eczema. RESEARCH: Gamma-linolenic acid (GLA), supplied in the form of evening primrose oil, has been studied for many years for its possible effects in arthritis and other inflammatory processes. In a randomized double-blind placebo-controlled study of rheumatoid arthritis (RA) sufferers, those receiving 1.4 grams of GLA daily experienced significant relief. GLA reduced the number of tender joints 36% and the swollen joint count by 28%. Those on placebo experienced no significant improvement or declined in condition. SIDE EFFECTS: No side effects expected at recommended dosage. High doses of fish oil may cause belching, flatulence, nausea, bloating, and diarrhea. INTERACTIONS AND SAFETY CONSIDERATIONS: Do not use if you are taking blood-thinning medication, have a history of seizure disorder, or are being treated with drugs that lower seizure threshold. Do not use before any surgical procedure. Large dosages should be accompanied by extra vitamin E. OTHER CONSIDERATIONS: Consult a health care practitioner before use if you are pregnant or breastfeeding. Keep out of reach of children.