Enhanced B Complex from webber naturals® is a comprehensive formula with 8 essential B vitamins, plus choline and inositol. The B vitamins are provided in their most bioavailable forms such as benfotiamine for vitamin B1 (1) and the biologically active methylcobalamin for vitamin B12. (2), B vitamins are water soluble and are not stored in the body, with the exception of vitamin B12, which is mostly stored in the liver. (3,4) Niacin, pantothenic acid, riboflavin, vitamin B6, and vitamin B12 help in energy metabolism and tissue formation, while thiamine supports energy production. (5,6) Together they serve as a source of vitamins to support biological functions that play a key role in the maintenance of good health. (7), Folate, along with vitamins B6 and B12, help form red blood cells. (8,9,10,11) Vitamin B12 also helps in the normal function of the immune system (12), while biotin helps maintain healthy hair, nail, mucous membranes, and skin. (13,14), Choline and inositol play a complex role in the physiology of the human body. (15,16,17) Choline helps support liver function. (18), Features and benefits : Helps to form red blood cells, Helps to maintain healthy hair, nail, mucous membranes and/or skin, Helps to prevent niacin/ vitamin B3, vitamin B6, and vitamin B12 deficiency, Helps to maintain the body's ability to metabolize nutrients and helps in tissue formation,Helps to prevent thiamine deficiency which helps supports normal growth, Helps to maintain healthy metabolism and support liver function, Helps to support normal early fetal development (brain and spinal cord). Helps to reduce the risk of neural tube defects when taken daily at least three months prior to becoming pregnant and during early pregnancy, Contains a complete spectrum of B vitamins, One-per-day formula, No gluten, Sugar free, Non-GMO, Free of artificial colours, preservatives, and sweeteners, No dairy, starch, wheat, yeast, soy, egg, fish, shellfish, animal products, salt, or tree nuts, Suitable for vegetarians and vegans,NPN 80078042 Recommended dosage (adults) : 1 capsule daily with food or as directed by a physician, Servings : 100 days,Warnings and Precautions : Keep out of reach of children, Storage : For product freshness, protect from heat and humidity, References : 1. Xie F, Cheng Z, Li S, et al. Pharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride. J Clin Pharmacol. 2014; 54(6):688-695. 2. Paul C, Brady DM. Comparative bioavailability and utilization of particular forms of B12 supplements with potential to mitigate B12-related genetic polymorphisms. Integr Med. 2017; 16(10):42-49. 3. Bruno EJ Jr, Ziegenfuss TN. Water-soluble vitamins: research update. Curr Sports Med Rep. 2005; 4(4):207-213. 4. Joske RA. The vitamin B-12 content of the human liver tissue obtained by aspiration biopsy. Gut. 1963; 4(3): 231-235. 5. Higdon J. An Evidence Based Approach to Vitamin and Minerals. New York: Thieme Publishers, 2003:1–38; 48-64. 6. Gaby AR. Nutritional Medicine. Concord NH, Fritz Perlberg Publishing, 2011:62-66. 7. National Research Council. Diet and Health: Implications for Reducing Chronic Disease Risk. Washington, DC: The National Academies Press, 1989. https://doi.org/10.17226/1222. 8. Mahmood L. The metabolic processes of folic acid and vitamin B12 deficiency. J Health Res Rev [serial online]. 2014 [cited 2019 May 1]; 1:5-9. 9. Bickers JN, Brown CL, Sprague CC. Pyridoxine responsive anemia. Blood. 1962; 19(3):304-312. 10. Chan CQ, Low LL, Lee KH. Oral vitamin B12 replacement for the treatment of pernicious anemia. Front. Med. 2016; 3:38. https://doi.org/10.3389/fmed.2016.00038 11. Al Khatib L, Obeid O, Sibai AM, et al. Folate deficiency is associated with nutritional anaemia in Lebanese women of childbearing age. Public Health Nutr. 2006; 9:921-917. 12. Erkurt MA, Aydogdu I, Dikilitaş M, et al. Effects of cyanocobalamin on immunity in patients with pernicious anemia. Med Princ Pract. 2008; 17:131-135. 13. National Academy of Sciences. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington; National Academies Press, 2006:197-200. 14. Colombo VE, Gerber F, Bronhofer M, et al. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. J Am Acad Dermatol. 1990; 23(6 Pt 1):1127-1132. 15. Zeisel SH, Da Costa KA. Choline: An essential nutrient for public health. Nutr Rev. 2009; 67:615-623. 16. Gaby AR. Nutritional Medicine. Concord NH, Fritz Perlberg Publishing, 2011:219-221. 17. Schellack N. B-complex vitamin deficiency and supplementation. S Afr Pharml J. 2015; 82:28-32.